Partial reversal of aging achieved in mice

November 30th, 2010 | by geo |

This has to make Ray Kurzweil happy. Maybe humans are next?

DePinho_605

Researchers led by Ronald A. DePinho (above), a Harvard Medical School professor of genetics, say their work shows for the first time a dramatic reversal of many aspects of age-related degeneration in mice, a milestone in aging science achieved by engineering mice with a controllable telomerase gene. The projection of chromosomes seen here shows telomeres (highlighted in red) on their ends. Read the article here…….

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  1. 8 Responses to “Partial reversal of aging achieved in mice”

  2. By Danny on Mar 28, 2011 | Reply

    What is the point of the elongated life 20 years from now… (thats the time it will move from mice to humans after clinical trails in which thousands in Africa will lose their lives under the coverup of vacsination)

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  8. By アバクロ on Dec 13, 2011 | Reply

    the point of the elongated life 20 years from now… (thats the time it will move from mice to humans after clinical trails in which thousands in Africa will lose their lives under the coverup of vacsination)

    Most do believe quality is better then quantity.

  9. By Dane Q. Love on Jun 6, 2013 | Reply

    While TERRA biogenesis and regulation have been extensively studied, a lack of reproducible experimental tools to alter TERRA cellular levels accounts for the sparse knowledge of TERRA-associated functions. Most of the putative roles so far ascribed to TERRA were deduced from in vitro experiments where short TERRA-like RNA oligonucleotides were employed. Such in vitro experiments have suggested that TERRA might regulate telomere length homeostasis, telomere replication and telomeric DNA condensation [6] , [12] – [14] . In particular, TERRA-like oligonucleotides strongly inhibited telomerase activity in telomeric repeat amplification protocol (TRAP) and telomerase direct assays [6] , [14] . Therefore, it is generally assumed that TERRA acts as a general inhibitor of telomerase-mediated telomere elongation and a few indirect in vivo evidences apparently support this assumption. A budding yeast telomere artificially forced to transcribe underwent shortening, while the length of the remaining telomeres was unaffected [15] . Yeast mutants with compromised Rat1p RNA exonuclease activity bear higher amounts of TERRA molecules and shorter telomeres as compared to wild type counterparts [16] . Finally, telomeres are shorter in cells established from ICF patients than in cells from healthy donors [10] . Nevertheless, it has not been directly tested whether the telomere shortening observed in these different cellular systems truly derives from telomerase inhibition. Thus, the actual biological relevance of the ability of TERRA-like oligonucleotides to inhibit telomerase activity in vitro still remains to be assessed.

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